Table 1 Antihypertensive drugs used among 1,875 pregnant women with HDP in the TMM BirThree cohort study

From: Antihypertensive drug use during pregnancy in Japan

For one year before pregnancy diagnosis

From pregnancy diagnosis to early pregnancy

From early pregnancy to mid pregnancy

Antihypertensives

n

%

Antihypertensives

n

%

Antihypertensives

n

%

Any antihypertensives

55

2.9

Any antihypertensives

55

2.9

Any antihypertensives

63

3.4

 Amlodipine

18

32.7

Methyldopaa

42

76.4

Methyldopaa

51

81.0

 Methyldopaa

17

30.9

Hydralazinea

8

14.5

Hydralazinea

10

15.9

 Nifedipinea

7

12.7

Labetalola

8

14.5

Nifedipinea

10

15.9

 Hydralazinea

5

9.1

Amlodipine

4

7.3

Labetalola

8

12.7

 Candesartan

4

7.3

Nifedipinea

1

1.8

Amlodipine

2

3.2

 Labetalola

3

5.5

Spironolactone

1

1.8

Atenolol

1

1.6

 Valsartan

3

5.5

Propranolol

1

1.8

Betaxolol

1

1.6

 Benidipine

3

5.5

Betaxolol

1

1.8

   

 Propranolol

2

3.6

Candesartan

1

1.8

   

 Furosemide

1

1.8

Trichlormethiazide

1

1.8

   

 Losartan

1

1.8

Eplerenone

1

1.8

   

 Spironolactone

1

1.8

Azelnidipine

1

1.8

   

 Irbesartan

1

1.8

      

 Betaxolol

1

1.8

      

 Telmisartan

1

1.8

      

 Azelnidipine

1

1.8

      

 Cilnidipine

1

1.8

      

 Urapidil

1

1.8

      

 Azilsartan

1

1.8

      
  1. HDP hypertensive disorder of pregnancy, TMM Tohoku Medical Megabank Organization
  2. aAntihypertensives recommended for HDP in the clinical practice guidelines in 2020 from the Japan Society of Obstetrics and Gynecology (nifedipine; from 20 weeks of pregnancy)