Table 1 Biometric and biochemical analysis

From: Sodium glucose cotransporter 2 inhibitor suppresses renal injury in rats with renal congestion

 

0.5% CMC

Tofogliflozin

n

12

12

BW (mg)

233.1 ± 11.4

237.5 ± 13.0

Kidney (mg/g BW)a

 Right non-congested

4.48 ± 0.28

4.35 ± 0.31

 Left congested

6.04 ± 0.57†

4.89 ± 0.46†, #

Renal water content (%)a,b

 Right non-congested

78.5 ± 0.5

78.2 ± 0.5

 Left congested

85.8 ± 0.6†

82.4 ± 0.6†, #

Heart (mg/g BW)

3.28 ± 0.22

3.26 ± 0.16

Liver (mg/g BW)

40.6 ± 2.3

39.9 ± 2.6

Serum

 TP (g/dL)

5.15 ± 0.61

5.36 ± 0.40

 Alb (g/dL)

3.20 ± 0.49

3.35 ± 0.24

 BUN (mg/dL)

24.0 ± 0.46

19.9 ± 0.36*

 Cr (mg/dL)

0.30 ± 0.03

0.26 ± 0.04*

 UA (mg/dL)

1.22 ± 0.34

1.14 ± 0.33

 Na (mEq/L)

136.8 ± 1.4

139.2 ± 0.7

 K (mEq/L)

5.90 ± 0.26

4.88 ± 0.20*

 Cl (mEq/L)

100.2 ± 0.8

99.5 ± 0.5

 Ca (mEq/L)

10.4 ± 0.3

10.7 ± 0.2

 IP (mg/dL)

8.1 ± 0.2

9.5 ± 0.2

 T-cho (mg/dL)

68.3 ± 2.0

69.3 ± 2.0

 Glu (mg/dL)

270.1 ± 11.5

291.3 ± 15.4

  1. Values are mean ± SEM
  2. BW body weight, TP total protein, Alb albumin, BUN blood urea nitrogen, Cr creatinine, UA uric acid, Na sodium, K potassium, Cl chloride, Ca calcium, IP inorganic phosphate, T-Cho total cholesterol
  3. *P < 0.05 versus rats without tofogliflozin treatment (CMC) by Mann–Whitney U test
  4. †P < 0.05 versus the right non-congested kidney in each group
  5. #P < 0.05 versus the left congested kidney without tofogliflozin treatment by Steel-Dwass test
  6. aKruskal–Wallis test followed by Steel-Dwass post hoc test was used
  7. bn = 7 per group
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