Table 2 Association between cancer history and the risk for cardiovascular disease

From: Risk of cancer history in cardiovascular disease among individuals with hypertension

 

Cancer History (–)

Cancer History (+)

Number

721,089

26,531

Composite Endpoint

 Number of Events

64,264

2890

 Incidence (per 10,000 person-years)

273.6 (271.5–275.7)

389.3 (375.4–403.7)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.42 (1.37–1.47)

 Model 2

1 [Reference]

1.19 (1.15–1.24)

 Model 3

1 [Reference]

1.21 (1.17–1.26)

Myocardial Infarction

 Number of Events

3738

133

 Incidence (per 10,000 person-years)

14.9 (14.4–15.4)

16.5 (13.9–19.6)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.12 (0.94–1.33)

 Model 2

1 [Reference]

1.00 (0.84–1.19)

 Model 3

1 [Reference]

1.07 (0.90–1.27)

Angina Pectoris

 Number of Events

26,007

1088

 Incidence (per 10,000 person-years)

106.4 (105.1–107.7)

139.2 (131.2–147.8)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.31 (1.23–1.39)

 Model 2

1 [Reference]

1.12 (1.05–1.19)

 Model 3

1 [Reference]

1.13 (1.06–1.20)

Stroke

 Number of Events

14,938

663

 Incidence (per 10,000 person-years)

60.3 (59.3–61.2)

83.6 (77.5–90.3)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.39 (1.28–1.50)

 Model 2

1 [Reference]

1.10 (1.01–1.19)

 Model 3

1 [Reference]

1.14 (1.06–1.24)

Heart Failure

 Number of Events

33,279

1573

 Incidence (per 10,000 person-years)

136.6 (135.1–138.1)

203.1 (193.3–213.4)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.50 (1.43–1.58)

 Model 2

1 [Reference]

1.28 (1.22–1.35)

 Model 3

1 [Reference]

1.31 (1.25–1.38)

Atrial Fibrillation

 Number of Events

8089

399

 Incidence (per 10,000 person-years)

32.4 (31.7–33.1)

49.9 (45.3–55.1)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.56 (1.41–1.72)

 Model 2

1 [Reference]

1.20 (1.09–1.33)

 Model 3

1 [Reference]

1.22 (1.10–1.35)

  1. We performed the Cox proportional hazard regression model to examine the association between cancer history and the risk of cardiovascular disease. Model 1 is unadjusted. Model 2 includes adjustment for age and sex. Model 3 includes adjustment for age, sex, systolic blood pressure, obesity, diabetes mellitus, dyslipidemia, cigarette smoking, alcohol consumption, and physical inactivity. The incidence rate was per 10,000 person-years
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