Table 3 Association of cancer history and chemotherapy with the risk for cardiovascular disease

From: Risk of cancer history in cardiovascular disease among individuals with hypertension

 

Cancer History (–)

Cancer History (+) Chemotherapy (-)

Cancer History (+) Chemotherapy (+)

Number

721,089

25,175

1356

Composite Endpoint

 Number of Events

64,264

2681

209

 Incidence (per 10,000 person-years)

273.6 (271.5–275.7)

378.2 (364.2–392.8)

624.1 (545.0–714.7)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.38 (1.33–1.43)

2.27 (1.98–2.60)

 Model 2

1 [Reference]

1.15 (1.11–1.20)

2.03 (1.77–2.32)

 Model 3

1 [Reference]

1.18 (1.13–1.22)

2.09 (1.82–2.39)

Myocardial Infarction

 Number of Events

3738

119

14

 Incidence (per 10,000 person-years)

14.9 (14.4–15.4)

15.5 (13.0–18.6)

37.7 (22.3–63.7)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.05 (0.88–1.26)

2.58 (1.53–4.36)

 Model 2

1 [Reference]

0.94 (0.78–1.13)

2.40 (1.42–4.06)

 Model 3

1 [Reference]

1.00 (0.83–1.20)

2.58 (1.53–4.37)

Angina Pectoris

 Number of Events

26,007

1020

68

 Incidence (per 10,000 person-years)

106.4 (105.1–107.7)

136.8 (128.7–145.5)

189.6 (149.5–240.5)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.29 (1.21–1.37)

1.78 (1.40–2.26)

 Model 2

1 [Reference]

1.10 (1.03–1.17)

1.61 (1.27–2.04)

 Model 3

1 [Reference]

1.11 (1.04–1.18)

1.62 (1.28–2.06)

Stroke

 Number of Events

14,938

628

35

 Incidence (per 10,000 person-years)

60.3 (59.3–61.2)

83.1 (76.8–89.8)

95.7 (68.7–133.3)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.38 (1.27–1.49)

1.59 (1.14–2.21)

 Model 2

1 [Reference]

1.08 (1.00–1.18)

1.36 (0.98–1.90)

 Model 3

1 [Reference]

1.13 (1.04–1.22)

1.46 (1.05–2.04)

Heart Failure

 Number of Events

33,279

1435

138

 Incidence (per 10,000 person-years)

136.6 (135.1–138.1)

194.1 (184.3–204.4)

393.4 (333.0–464.9)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.43 (1.36–1.51)

2.92 (2.47–3.45)

 Model 2

1 [Reference]

1.22 (1.16–1.29)

2.63 (2.23–3.11)

 Model 3

1 [Reference]

1.25 (1.19–1.32)

2.75 (2.32–3.25)

Atrial Fibrillation

 Number of Events

8089

375

24

 Incidence (per 10000 person-years)

32.4 (31.7–33.1)

49.2 (44.5–54.4)

65.3 (43.8–97.4)

 Hazard Ratio (95% Confidence Interval)

 Model 1 (Unadjusted)

1 [Reference]

1.53 (1.38–1.70)

2.04 (1.37–3.05)

 Model 2

1 [Reference]

1.18 (1.06–1.31)

1.71 (1.15–2.55)

 Model 3

1 [Reference]

1.19 (1.07–1.32)

1.78 (1.19–2.66)

  1. We performed the Cox proportional hazard regression model to examine the association between cancer history and the risk of cardiovascular disease. Individuals were divided into three groups: cancer history absent, cancer history present without chemotherapy, cancer history present with chemotherapy. Model 1 is unadjusted. Model 2 includes adjustment for age and sex. Model 3 includes adjustment for age, sex, systolic blood pressure, obesity, diabetes mellitus, dyslipidemia, cigarette smoking, alcohol consumption, and physical inactivity. The incidence rate was per 10,000 person-years
Back to article page