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Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population

Hypertension Research volume 47, pages 2284–2294 (2024)Cite this article

A Comment to this article was published on 11 September 2024

Abstract

Although previous polygenic risk score (PRS) studies for cardiovascular disease (CVD) focused on incidence, few studies addressed CVD mortality and quantified risks by environmental exposures in different genetic liability groups. This prospective study aimed to examine the associations of blood pressure PRS with all-cause and CVD mortality and to quantify the attributable risk by modifiable lifestyles across different PRS strata. 9,296 participants in the Japan Multi-Institutional Collaborative Cohort Study without hypertension at baseline were analyzed in this analysis. PRS for systolic blood pressure and diastolic blood pressure (PRSSBP and PRSDBP) were developed using publicly available Biobank Japan GWAS summary statistics. CVD-related mortality was defined by the International Classification of Diseases 10th version (I00-I99). Cox-proportional hazard model was used to examine associations of PRSs and lifestyle variables (smoking, drinking, and dietary sodium intake) with mortality. During a median 12.6-year follow-up period, we observed 273 all-cause and 41 CVD mortality cases. Compared to the middle PRS group (20–80th percentile), adjusted hazard ratios for CVD mortality at the top PRS group ( > 90th percentile) were 3.67 for PRSSBP and 2.92 for PRSDBP. Attributable risks of CVD mortality by modifiable lifestyles were higher in the high PRS group ( > 80th percentile) compared with the low PRS group (0–80th percentile). In summary, blood pressure PRS is associated with CVD mortality in the general Japanese population. Our study implies that integrating PRS with lifestyle could contribute to identify target populations for lifestyle intervention even though improvement of discriminatory ability by PRS alone is limited.

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Acknowledgements

The authors would like to thank all contributors of the J-MICC collaborators. The list of collaborators is shown at https://jmicc.com/en/contributors. The current committee members of J-MICC Study Group (As of 5th June 2023): Keitaro Matsuo (Principal investigator), Kenji Wakai, Nobuaki Michihata, Hiroto Narimatsu, Kiyonori Kuriki, Asahi Hishida, Hidemi Ito, Sadao Suzuki, Yoshikuni Kita, Katsuyuki Miura, Teruhide Koyama, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Keitaro Tanaka, Chihaya Koriyama. We thank Dr. J.M. Dijkstra, Office of Research Administration, Fujita Health University, for the English proofreading of our manuscript.

for the J-MICC Study Group

Keitaro Matsuo (Principal investigator)10,11, Kenji Wakai3, Nobuaki Michihata12, Hiroto Narimatsu19-22, Kiyonori Kuriki15, Asahi Hishida3, Hidemi Ito10,11, Sadao Suzuki14, Yoshikuni Kita16, Katsuyuki Miura6, Teruhide Koyama5, Sakurako Katsuura-Kamano17, Hiroaki Ikezaki7,8, Keitaro Tanaka9, and Chihaya Koriyama13.

Funding

This study was supported by Grants-in-Aid for Scientific Research for Priority Areas of Cancer [No: 17015018] and Innovative Areas [No: 221S0001] and by JSPS KAKENHI Grants [Nos: 16H06277, 22H04923, and 20K18943] from the Japanese Ministry of Education, Culture, Sports, Science and Technology. This study was supported in part by funding for the BioBank Japan Project from the Japan Agency for Medical Research and development since April 2015, and the Ministry of Education, Culture, Sports, Science and Technology from April 2003 to March 2015.

Author information

Authors and Affiliations

  1. Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, 470-1192, Japan

    Ryosuke Fujii, Hiroshi Okumiyama, Yoshiki Tsuboi & Koji Suzuki

  2. Institute for Biomedicine, Eurac Research, Via A.Volta 21, Bolzano/Bozen, 39100, Italy

    Ryosuke Fujii

  3. Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Ryosuke Fujii, Asahi Hishida, Yasufumi Kato, Takashi Tamura & Kenji Wakai

  4. Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daikominami, Higashi-ku, Nagoya, 461-8673, Japan

    Masahiro Nakatochi

  5. Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan

    Naoyuki Takashima & Teruhide Koyama

  6. NCD Epidemiology Research Center, Shiga University of Medical Science, Tsukiwacho, Seta, Otsu, 520-2192, Japan

    Naoyuki Takashima, Aya Kadota & Katsuyuki Miura

  7. Department of Comprehensive General Internal Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Hiroaki Ikezaki & Hiroaki Ikezaki

  8. Department of General Internal Medicine, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Hiroaki Ikezaki & Hiroaki Ikezaki

  9. Department of Pharmacy, Saga University Hospital, 5-1-1 Nabeshima, Saga, 849-8501, Japan

    Chisato Shimanoe & Keitaro Tanaka

  10. Division of Cancer Information and Control, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan

    Hidemi Ito, Keitaro Matsuo & Keitaro Matsuo (Principal investigator)

  11. Division of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Hidemi Ito, Keitaro Matsuo & Keitaro Matsuo (Principal investigator)

  12. Cancer Prevention Center, Chiba Cancer Center Research Institute, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan

    Nobuaki Michihata

  13. Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan

    Shiroh Tanoue & Chihaya Koriyama

  14. Department of Public Health, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan

    Sadao Suzuki

  15. Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan

    Kiyonori Kuriki

  16. Faculty of Nursing Science, Tsuruga Nursing University, 78-2 Kizaki, Tsuruga, 914-0814, Japan

    Aya Kadota & Yoshikuni Kita

  17. Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan

    Takeshi Watanabe & Sakurako Katsuura-Kamano

  18. Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan

    Yukihide Momozawa

  19. Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, 210-0821, Japan

    Hiroto Narimatsu

  20. School of Health Innovation, Kanagawa University of Human Services, Kawasaki, 210-0821, Japan

    Hiroto Narimatsu

  21. Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, 241-8515, Japan

    Hiroto Narimatsu

  22. Department of Genetic Medicine, Kanagawa Cancer Center, Yokohama, 241-8515, Japan

    Hiroto Narimatsu

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  1. Ryosuke Fujii
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  2. Asahi Hishida
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for the J-MICC Study Group

  • Keitaro Matsuo (Principal investigator)
  • , Kenji Wakai
  • , Nobuaki Michihata
  • , Hiroto Narimatsu
  • , Kiyonori Kuriki
  • , Asahi Hishida
  • , Hidemi Ito
  • , Sadao Suzuki
  • , Yoshikuni Kita
  • , Katsuyuki Miura
  • , Teruhide Koyama
  • , Sakurako Katsuura-Kamano
  • , Hiroaki Ikezaki
  • , Keitaro Tanaka
  •  & Chihaya Koriyama

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Correspondence to Ryosuke Fujii.

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Fujii, R., Hishida, A., Nakatochi, M. et al. Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population. Hypertens Res 47, 2284–2294 (2024). https://doi.org/10.1038/s41440-024-01766-9

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