Table 3 Integrated discrimination improvement and net reclassification improvement for pulse pressure amplification

Cohort Endpoint Risk indicator	Integrated discrimination improvement		Net reclassification improvement
Cohort Endpoint Risk indicator	IDI (%)	P	NRI (%)	P
Discovery (n = 3945)
Cardiovascular
PPA < 1.3 vs ≥1.3	0.12 (−0.25, 0.50)	0.52	16.1 (1.73, 30.5)	0.028
Continuous	0.27 (−0.15, 0.69)	0.21	9.26 (−5.29, 23.8)	0.21
Coronary
PPA < 1.3 vs ≥1.3	0.41 (−0.41,1.22)	0.33	33.0 (11.9, 54.2)	0.002
Continuous	0.40 (−0.47, 1.27)	0.36	21.6 (−0.41, 43.7)	0.054
Replication (n = 1663)
Cardiovascular
PPA < 1.3 vs ≥1.3	0.50 (−0.72, 1.71)	0.42	33.7 (10.0, 57.4)	0.005
Continuous	0.76 (−0.35, 1.88)	0.18	22.7 (−1.74, 47.1)	0.069
Coronary
PPA < 1.3 vs ≥1.3	0.89 (−2.08, 3.85)	0.56	44.9 (11.7, 78.2)	0.008
Continuous	1.08 (−0.60, 2.76)	0.21	30.2 (−4.45, 64.8)	0.088
All (n = 5608)
Cardiovascular
PPA < 1.3 vs ≥1.3	0.16 (−0.20, 0.53)	0.38	15.2 (2.76, 27.6)	0.017
Continuous	0.29 (−0.10, 0.68)	0.15	11.8 (−0.70, 24.3)	0.064
Coronary
PPA < 1.3 vs ≥1.3	0.49 (−0.37, 1.34)	0.26	30.8 (12.7,48.9)	0.001
Continuous	0.46 (−0.28, 1.21)	0.22	21.5 (2.85, 40.2)	0.024

The base model included cohort (random effect), sex, age, body mass index, heart rate, smoking and drinking, total-to-HDL serum cholesterol ratio, estimated glomerular filtration rate, antihypertensive drug intake, history of cardiovascular disease, and diabetes. The integrated discrimination improvement (IDI) is the difference between the discrimination slopes of the base model and the base model extended by PPA. The discrimination slope is the difference in predicted probabilities (%) between participants without and with an endpoint. The net reclassification index (NRI) is the sum of the percentages of participants reclassified correctly in individuals without and with an endpoint. IDI and NRI estimates are given with 95% confidence interval

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