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  • JSH2025 Systematic Review Series: Clinical Questions in the Management of Hypertension
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Updated meta-analysis for antihypertensive treatment guided by home blood pressure compared to treatment based on office blood pressure: systematic review

Hypertension Research volume 48, pages 1839–1845 (2025)Cite this article

Abstract

Home blood pressure (BP) measurement is widely used, and home BP plays a central role in hypertension management in clinical practice in Japan. We updated the systematic review to determine whether home BP-based antihypertensive treatment is superior to office BP-based treatment in improving clinical outcomes, including BP levels, in adult patients with essential hypertension. A literature search identified 14 randomized controlled trials (RCTs). The results of meta-analysis revealed that home BP-based antihypertensive treatment was significantly associated with greater reductions in ambulatory systolic BP by 2.73 mmHg (95% confidence interval [CI], –5.23 to –2.22 mmHg; p = 0.03) and ambulatory diastolic BP by 1.61 mmHg (95% CI, –3.21 to –0.01 mmHg; p = 0.05) compared to office BP-based treatment. No RCTs evaluating cardiovascular outcomes other than ambulatory BP reduction were identified. Consistent with the previous review, this updated meta-analysis revealed home BP-based antihypertensive treatment is strongly recommended over office BP-based treatment for BP control in patients with essential hypertension.

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Acknowledgements

This study was supported by the JSH guideline committee.

Author information

Author notes

  1. These authors contributed equally: Tatsuya Maruhashi, Yukako Tatsumi

Authors and Affiliations

  1. Department of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan

    Tatsuya Maruhashi

  2. Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan

    Yukako Tatsumi & Takayoshi Ohkubo

  3. Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan

    Michihiro Satoh

  4. Department of Pharmacy, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

    Michihiro Satoh

  5. YCU Co-Creation Innovation Center, Yokohama City University, Yokohama, Japan

    Yusuke Kobayashi

  6. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Yusuke Kobayashi

  7. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan

    Yukako Ogoyama

  8. Health Administration Center, University of the Ryukyus, Okinawa, Japan

    Atsushi Sakima

  9. Department of Preventive Medicine & Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Hisatomi Arima

Authors
  1. Tatsuya Maruhashi
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  2. Yukako Tatsumi
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  3. Michihiro Satoh
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  4. Yusuke Kobayashi
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  5. Yukako Ogoyama
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  6. Atsushi Sakima
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  7. Hisatomi Arima
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  8. Takayoshi Ohkubo
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Corresponding author

Correspondence to Takayoshi Ohkubo.

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TO received honoraria (lecture fee) and a joint research grant from Omron Healthcare Co., Ltd.

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Maruhashi, T., Tatsumi, Y., Satoh, M. et al. Updated meta-analysis for antihypertensive treatment guided by home blood pressure compared to treatment based on office blood pressure: systematic review. Hypertens Res 48, 1839–1845 (2025). https://doi.org/10.1038/s41440-024-02072-0

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