Fig. 3
Subgroup analysis for clinical outcomes. A Composite Kidney Outcome No significant overall association is found between RASi discontinuation and the composite kidney outcome. However, a significant qualitative interaction by age is observed, with a trend toward an increased risk of the composite kidney outcome in patients under 70 years. Boxes and bars represent adjusted hazard ratios and 95% CI, respectively. B All-Cause Death No significant overall association is found between RASi discontinuation and all-cause death. However, a significant interaction by age is observed, with a trend toward an increased risk of all-cause death in patients under 70 years. Boxes and bars represent adjusted hazard ratios and 95% CI, respectively. C Severe Hyperkalemia The Discontinuation group consistently shows a lower hazard of severe hyperkalemia (serum potassium levels >6.5 mEq/L) across all prespecified subgroups. Boxes and bars represent adjusted hazard ratios and 95% CI, respectively. RASi renin-angiotensin system inhibitors, eGFR estimated glomerular filtration rate, UPCR urine protein-to-creatinine ratio, Cre creatinine, CI confidence interval
