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A rare case of intravascular papillary endothelial hyperplasia (Masson’s tumor) of the penis

Intravascular papillary endothelial hyperplasia (IPEH), or Masson’s tumor, is an uncommon, benign vascular lesion that can mimic malignant neoplasms. Although commonly found in the skin and soft tissues, its occurrence in the penis is extremely rare. We report the case of a 51-year-old male who presented with a painless, progressively enlarging penile mass. Imaging suggested a benign etiology, and the patient underwent surgical excision. Histopathological analysis confirmed the diagnosis of Masson’s tumor, revealing papillary endothelial proliferation within a thrombotic background. The postoperative course was uneventful, with satisfactory wound healing and no recurrence at follow-up. While rare, penile Masson’s tumor should be considered in the differential diagnosis of vascular penile lesions to avoid misdiagnosis and overtreatment. Surgical excision remains the definitive treatment, with excellent prognosis.

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Fig. 1: Gross and histopathological features of Masson’s tumor lesion, pre- and postoperatively.

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All relevant data supporting the findings of this study are included in the manuscript. Additional data may be made available upon reasonable request from the corresponding author.

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Authors and Affiliations

Authors

Contributions

Faysal A Yafi: Study conception, manuscript supervision, critical revisions. Muhammed A M Hammad: Data collection, manuscript drafting, literature review. Elia Abou Chawareb: manuscript drafting, literature review. Jeffrey Lee, Mohammed Mahdi: Data interpretation, manuscript editing. Maryam Ahmadi, Giovanna Giannico: Histopathological analysis, pathology review, manuscript revisions. All authors have reviewed and approved the final manuscript and contributed substantially to the work.

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Correspondence to Muhammed A. M. Hammad.

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Competing interests

MAMH, EAB, JL, MM, MA, GG -no disclosures FAY- consultant for Coloplast, Cynosure, Antares Pharma, Clarus Pharmaceuticals, Acerus Pharma.

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Hammad, M.A.M., Abou Chawareb, E., Lee, J. et al. A rare case of intravascular papillary endothelial hyperplasia (Masson’s tumor) of the penis. Int J Impot Res 37, 794–796 (2025). https://doi.org/10.1038/s41443-025-01136-0

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