Table 1 Results for the successfully replicated SNPs in discovery, replication and combined sample
From: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
SNP ID | Chrom | Position | Closest gene | Allele ½ | EAF | Discovery (n = 38,292) | Replication EU (n = 47,227) | Combined EU (n = 85,519) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta | SE | p-value | Beta | SE | p-value | Beta | SE | p-value | ||||||
Whole body lean mass | ||||||||||||||
rs2943656 | 2 | 226830162 | IRSI | A/G | 0.38 | −0.17 | 0.03 | 2.5 × 10−7 | −0.13 | 0.03 | 8.0 × 10−6 | −0.14 | 0.02 | 1.5 × 10−11 |
rs9991501 | 4 | 88477507 | HSD17B11 | T/C | 0.04 | −0.61 | 0.01 | 2.9 × 10−8 | −0.26 | 0.08 | 1.9 × 10−3 | −0.39 | 0.07 | 5.8 × 10−9 |
rs2287926 | 5 | 82851164 | VCAN | A/G | 0.12 | 0.24 | 0.05 | 8.6 × 10−7 | 0.15 | 0.04 | 8.5 × 10−4 | 0.19 | 0.03 | 7.5 × 10−9 |
rs4842924 | 15 | 82378611 | ADAMTSL3 | T/C | 0.52 | −0.17 | 0.03 | 1.4 × 10−7 | −0.08 | 0.03 | 3.9 × 10−3 | −0.12 | 0.02 | 1.4 × 10−8 |
rs9936385 | 16 | 52376670 | FTO | T/C | 0.61 | −0.17 | 0.03 | 1.1 × 10−6 | −0.11 | 0.03 | 1.6 × 10−4 | −0.14 | 0.02 | 1.4 × 10−9 |
SNP ID | Chrom | Position | Closest gene | Allele ½ | EAF | Discovery (n = 28,330) | Replication EU (n = 42,360) | Combined EU (n = 70,690) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta | SE | p -value | Beta | SE | p -value | Beta | SE | p -value | ||||||
Appendicular lean mass | ||||||||||||||
rs2943656 | 2 | 226830162 | IRS1 | A/G | 0.38 | −0.10 | 0.02 | 1.1 × 10−6 | −0.06 | 0.01 | 2.2 × 10−5 | −0.07 | 0.01 | 2.9 × 10−10 |
rs2287926 | 5 | 82851164 | VCAN | A/G | 0.13 | 0.14 | 0.03 | 8.1 × 10−7 | 0.08 | 0.02 | 3.5 × 10−4 | 0.10 | 0.02 | 4.5 × 10−9 |
rs4842924 | 15 | 82378611 | ADAMTSL3 | T/C | 0.52 | −0.09 | 0.02 | 1.2 × 10−6 | −0.05 | 0.02 | 1.6 × 10−3 | −0.06 | 0.01 | 5.0 × 10−8 |
