Fig. 9

Schematic model of the identified C/EBPα-miR-182 interaction. During myeloid differentiation (lower panel), C/EBPα is active, binds to the MIR182 promoter and reduces miR-182 expression. Elevated miR-182 levels, especially in AML with defective C/EBPα DNA binding capacity, reduce the amount of functional C/EBPα protein by direct binding to the CEBPA 3′UTR and block myeloid differentiation (upper panel). C/EBPα is a critical transcription factor involved in myelopoiesis and its inactivation is associated with acute myeloid leukemia (AML). Here the authors show a negative feedback loop between C/EBPα and miR-182 and identify this miRNA as a marker of high-risk AML