Fig. 1
From: Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila
Enteric dysbiosis aggravates neurodegeneration in a Drosophila Alzheimer’s disease (AD) model. a Histology analysis of degenerated brain tissues (brain section; 14 days postinfection, dpi; n = 10) and immunohistochemistry staining of apoptosis markers (whole brain; 10 dpi; n = 15). b, c Negative geotaxis assay of locomotion behavior (n = 120 in each group) b and lifespan analysis (n = 100 in each group) c. elav >Aβ42 transgenic or control (elav alone) flies intestinally infected with or without Ecc15. Error bars represent the SD. The definition of neurodegeneration index is shown in figure legend of Supplementary Fig. 1. H&E, haematoxylin and eosin. **P < 0.01, ***P < 0.001; NS not significant. Scale bars, 50 μm
