Fig. 1
From: Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer
The 47 discovery breast tumors have typical mutational profiles. For each sample (sample IDs at bottom of panel 1D), we show a the number of mutations per Mb; b if a mutation is present in one of the 12 known breast cancer driver genes or c in non-driver genes that are mutated in at least 3 (8%) discovery samples; and d genome-wide SNV substitution frequencies; CG–TA mutations are the most common. e The mutational profile in discovery sample TCGA-A2-A0D1 (SNV substitution types colored-coded as in panel 1D). The X-axis shows all mutations ordered by mutation index (from the first mutated position on chromosome 1 to last mutated position on chromosome X) and the Y-axis represents the average distance between each mutation and its two neighboring mutations, in log-scale. f Shows three kataegis loci (red rectangles) on chromosome 8
