Table 3 Lead SNPs for the eight bivariate association signal with TBLH-BMD and TB-LM

From: Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Locus

SNP

CHR

Position

A1

A2

EAF

Beta TBLH-BMD

P TBLH-BMD

Beta TBLM

P TBLM

P bivariate

1p36.12

rs6684375

1

22579021

T

C

0.19

0.0842

2.47E-06

−0.0273

0.14

4.69E-09

2q24.3

rs6726821

2

166286360

G

T

0.45

−0.0769

2.95E-08

−0.0104

0.48

3.56E-08

4q22.1

rs7672749

4

89017308

A

G

0.09

0.0822

4.35E-04

−0.0591

0.01

3.29E-08

7q31.31

rs917727

7

120805815

T

C

0.29

0.1289

5.29E-17

−0.0042

0.77

3.07E-20

11q13.2

rs12284933

11

68076065

A

G

0.24

−0.0969

1.85E-09

−0.0699

1.49E-05

2.19E-09

13q14.11

rs9525638

13

42026577

C

T

0.42

0.0756

6.42E-08

−0.0006

0.97

1.35E-08

14q2.12

rs754388

14

92185163

G

C

0.18

−0.0862

3.26E-06

0.0210

0.24

3.36E-08

17p11.2

rs7501812

17

17691632

G

A

0.41

0.0431

0.002

−0.0563

5.53E-05

1.44E-10

  1. Estimates were derived from 10,414 children participants of four different pediatric studies worldwide. Beta coefficients and allele frequencies (EAF) are reported for the A1 allele
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