Fig. 2

Different junctional diversity at RI sites in wild-type and Polq ^−/− cells. a Schematic representation of junctions found at RI sites: (i) simple deletions that are without insertions (in grey), (ii) complex junctions that contain insertions, which display sequence identity to the transfected DNA but in a reverse complement (RC) orientation (in red), and (iii) complex junctions with untraceable miscellaneous insertions (in pink); *** denotes p < 0.001 in Fischer’s exact test. b Two representative cases of insertion-containing transfected DNA-genome junctions. Junctional sequences that are identical to the transfected (foreign) DNA (in bold) or the mouse genome are marked. Micro-homologous sequences are boxed. Identical sequences in a RC orientation are underlined