Fig. 2
From: Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
Isoproterenol-induced arrhythmias in PKP2-cKO hearts. a Incidence of spontaneous, and of isoproterenol-induced (ISO) PVCs during 20 min of recording in anesthetized PKP2-cKO mice as a function of days post-tamoxifen injection (dpi). Data reported as percent of total animals studied per time point and condition; number of animals in parenthesis at top of each bar. Numbers inside bars indicate mean ± SEM of ventricular extrasystoles. b Example of ISO-induced non-sustained ventricular tachycardia (NSVT) in a PKP2-cKO mouse. Scale bar = 500 ms. c Example of ISO-induced fatal ventricular tachycardia/fibrillation (VT/VF) in a PKP2-cKO mouse 16 days post tamoxifen injection. Scale bar = 500 ms
