Table 1 Assessment of clinical GvHD in transplanted animals
From: Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
Criteria | Grade 0 | Grade 1 | Grade 2 |
|---|---|---|---|
Weight loss | <10% | >10% to <25% | >25% |
Posture | Normal | Hunching noted only at rest | Severe hunching impairs movement |
Activity | Normal | Mild to moderately decreased | Stationary unless stimulated |
Fur texture | Normal | Mild to moderate ruffling | Severe ruffling/poor grooming |
Skin integrity | Normal | Scaling of paws/tail | Obvious areas of denuded skin |
