Fig. 4
From: Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum
CF synapse elimination in TrkB-PC-KO and p75NTR-PC-KO mice. a Representative traces of CF-EPSCs in a PC from a control (left, P21) and a TrkB-PC-KO (right, P26) mouse. Holding potential was −10 mV. Single traces recorded at different stimulus intensities were superimposed. b Frequency distribution histogram for the number of CFs innervating each PC in control (open columns, n = 67 PCs from 7 mice) and TrkB-PC-KO (filled columns, n = 71 PCs from 7 mice) mice during P21–P31 (P = 0.612, Mann–Whitney U-test). ns indicates no significant difference between the two groups. c, d Similar to a, b but for results from p75NTR-PC-KO and control mice during P21–P41. CF-EPSCs in c were recorded in cerebellar slices from a control (left, P39) and a p75NTR-PC-KO (right, P38) mouse. Sample sizes for d were 54 PCs from 6 control mice and 69 PCs from 8 p75NTR-PC-KO mice (P = 0.548, Mann–Whitney U-test). ns indicates no significant difference between the two groups. Scale bars: a and c, 10 ms and 1 nA
