Fig. 3
From: Pan-urologic cancer genomic subtypes that transcend tissue of origin
Pan-urologic cancer genomic subtypes have analogs of previously described cancer type-specific histological or molecular subtypes. a Significance of overlap between the pan-urologic cancer subtype assignments made in the present study (rows), with histological- or molecular-based subtype assignments (columns, also compiled in Supplementary Data 1) made previously 5, 6, 10 for a subset of cases. P-values by one-sided Fisher’s exact test. RCC, renal cell carcinoma (KICH, KIRC, KIRP). “meth.” and “hypermeth.”, DNA methylation and DNA hyper-methylation, respectively. “lum. immune” and “immune undiff.”, BLCA mRNA-based subtypes luminal immune and immune undifferentiated, respectively17. PanCan12:squamous associated with “squamous” pan-cancer subtype by Hoadley et al.7 b Within TCGA KIRC cases, differences in patient overall survival among the pan-urologic c5, c6, and c7 genomic subtypes. c Within TCGA KIRP cases, differences in patient overall survival among the pan-urologic c1, c3, c5, and c6 genomic subtypes. d Within TCGA BLCA cases, differences in patient overall survival among the pan-urologic c1, c2, and c8 genomic subtypes. e Within an independent cohort of prostate cancer cases18, classified according to our pan-urologic genomic subtypes, differences in patient overall survival among the c2, c4, and c9 subtypes. For parts b-e, P-values by log-rank test. See also Supplementary Fig. 3
