Fig. 5
From: Pan-urologic cancer genomic subtypes that transcend tissue of origin
Differentially active pathways across pan-urologic genomic subtypes. a Across the genomic subtypes, heat map represents differential aggregate expression of mRNAs associated with metabolism pathways, along with expression of metabolism-related proteins (using values normalized within cancer type; gray, no data; GNG, gluconeogenesis). Pathway diagram represents core metabolic pathways, with differential expression patterns comparing tumors in groups c5, c8, or TGCT.c9 (subset c9 of TGCT type) with tumors in groups RCC.c6 (c6 of KIRC or KICH type), c1, or TGCT.c4, respectively (red, significantly higher in c5/c8/TGCT.c9). b Across the genomic subtypes, heat map represents differential aggregate expression of mRNAs associated with hypoxia, EMT, MAPK, NRF2-ARE, and cyclin D1 pathways, along with a proteomic MAPK signature (using values normalized within cancer type). Pathway diagrams represent relationships between the above pathways23,24,25,26, 53, 54, with differential expression patterns comparing tumors in groups c5, c8, or c9 with tumors in groups c7, c1, or c2, respectively (red, significantly higher in c5/c8/c9). c Across the genomic subtypes, heat map represents differential mRNA and protein features involved with Hippo pathway. Pathway diagrams represent differential expression patterns comparing tumors in groups c2, c4, or c5 with tumors in groups c9, c9, or c6, respectively (red, significantly higher in c2/c4/c5). See also Supplementary Fig. 5
