Fig. 5 | Nature Communications

Fig. 5

From: Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

Fig. 5

Fyn axis is essential for arthritis development. a Fyn-deficient mice failed to develop autoimmune arthritis following induction of the CAIA model both in hFcγRIIATg and hFcαRITg background. Arthritis score was graded blind as 0 (normal), 3 (mild), 6 (moderate), or 9 (severe). b, c Circulating levels of CII-specific antibodies in individual sera from WT, FcγRIIATg (b) and from FcαRITg (c) mice on the indicated backgrounds at day 10 after injection of antibodies. Mean ± s.e.m. (n = 4) (d) Lyn is essential for FcR-ITAMi-mediated protection of arthritis. Arthritis score evaluated as in a. e, f H&E staining of hind paws from representative indicated mice at day 10. Scale bars: 200 µm. Mean ± s.e.m (n = 8). **P < .01; two-way ANOVA test

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