Fig. 6 | Nature Communications

Fig. 6

From: Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

Fig. 6

Inactive SHP-1S591 is linked to arthritis development. a–c Immunostaining for the detection of phospho SHP-1Y536 (a), phospho SHP-1S591 (b), and phospho SykY525–526 (c) in hind leg sections of indicated mice subjected or not to the CAIA model. The corresponding quantifications of positive cells for phospho-SHP-1 on Y536 or S591 and phospho-Syk Y525/526 are shown on the right of each panel. Scale bars: 200 µm. **P < .01, ***P < .001; non significant ns, Mann–Whitney test. Sections of three mice/group were automatically quantified with the software CaloPix piloted in a blind manner. Data are presented as the mean ± s.e.m (n = 5)

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