Fig. 8
From: Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
The effects of CLDN4 and ncRNAs on tumor growth. SGC-7901 cells were subcutaneously injected at both right and left armpit regions of nude mice. After tumor formation, plasmids of CLDN4, lncRNAs and agomirs of miRNAs were injected into tumors of right side and their negative controls into left side. a Treatment of CLDN4 promoted xenograft tumor growth. b, c Treatment of miR-596 and miR-3620-3p suppressed xenograft tumor growth. d, e Treatment of pcDNA3.1-KRTAP5-AS1 and pcDNA3.1-TUBB2A promoted xenograft tumor growth. f, g miR-596 and miR-3620-3p treated tumors showed less CLDN4 expression. h miR-596 and miR-3620-3p treated tumors showed less IncRNA-KRTAP5-AS1 expression. i miR-3620-3p treated tumors showed less IncRNA-TUBB2A expression. Data are shown as mean ± s.d., n = 5 for each group. The data statistical significance is assessed by Student’s t-test. *P < 0.05, **P < 0.01
