Fig. 6
From: Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
Pharmacological inhibition of mast cell degranulation increases efficacy of AAT. a Kinetic of subcutaneously growing Panc02 tumors expressed as tumor volume. Panc02 tumor cells were transplanted into the flanks of C57Bl/6J mice. After randomization, animals were treated with 20 mg/kg DC101 or 25 mg/kg cromolyn in single and combinatorial therapy (n = 7/8/7/8; *p < 0.05; two-way ANOVA). b Weight of end-stage Panc02 tumors at day of euthanasia (n = 8/7/8/7; *p < 0.05; one-way ANOVA). c–e Histomorphometric quantification of BrdU+ CD105+ proliferating (c) and CD31+ total (d) tumor microvessels and of BrdU+ tumor area (e) (n = 8/7/8/7; *p < 0.05; one-way ANOVA). Results are shown as representative means ± s.e.m
