Fig. 7
From: IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
Inhibitory synaptic transmission is reduced in Igsf21 −/− mice. a, d Representative recordings of mIPSCs a and mEPSCs d from hippocampal CA1 pyramidal neurons in acute slices from Igsf21 +/+ and Igsf21 −/− mice. b, c Cumulative distributions of the mIPSC inter-event interval b and amplitude c. Insets in b and c display the mean frequency and amplitude (±s.e.m.), respectively. n = 15 cells from 7 Igsf21 +/+ mice and 17 cells from 7 Igsf21 −/− mice. Unpaired t-test, ***P < 0.0001 for frequency and P = 0.1857 for amplitude. e, f Cumulative distributions of the mEPSC inter-event interval e and amplitude f. Insets in e and f display the mean frequency and amplitude (±s.e.m.), respectively. n = 16 cells from 7 Igsf21 +/+ mice and 13 cells from 9 Igsf21 −/− mice. Unpaired t-test, P = 0.8658 for frequency and P = 0.1336 for amplitude. Data are presented as mean ± s.e.m
