Fig. 8
From: IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
Igsf21 −/− mice have a sensorimotor gating deficit. a There is no difference between Igsf21 +/+ and Igsf21 −/− littermates in the total distance traveled during the open field test (total 90 min). n = 15 male mice from each genotype, two-way ANOVA, F (1, 252) = 2.199, P = 0.1393 between genotypes. n.s., not significant. b There is no difference between Igsf21 +/+ and Igsf21 −/− littermates in latency to fall in the rotarod test. n = 15 male mice from each genotype, two-way ANOVA, F (1, 84) = 2.217, P = 0.1402 between genotypes. n.s., not significant. c There is no difference between Igsf21 +/+ and Igsf21 −/− littermates in mean startle amplitudes in the pulse-alone trials for the three test blocks (Block I: 6 consecutive pulse-alone trials; Block II, 8 pulse-alone trials interspersed with prepulse+pulse trials; Block III: 6 consecutive pulse-alone trials). n = 15 male mice from each genotype, two-way ANOVA, F (1, 84) = 2.663, P = 0.1064 between genotypes. n.s., not significant. d Igsf21 −/− mice display decreased pre-pulse inhibition (PPI). (Block II PPI, n = 15 male mice for each genotype, two-way ANOVA, F (1, 140) = 8.348, *P = 0.0045 between genotypes. # P = 0.0368 at 79 dB between the two genotypes by Bonferroni’s multiple comparisons test). Data are presented as mean ± s.e.m
