Fig. 2

Concentration and incubation time-dependent cleavage of the PCL denatonium or PCL carboxyfluorescein conjugates. a Cleavage (%) of the PCL (Cf-CLAN₃Q in Supplementary Table 1; Fig. 1a) as a function of MMP-8 concentration within 60 min. n = 10. b cleavage (%) of the peptide denatonium fragment (i.e., IAGQK-De in Supplementary Table 1; Fig. 1b) as a function of aminopeptidase concentration within 60 min. n = 5. c Impact of incubation time on cleavage (%) of the PCL using 900 ng/mL MMP-8 n = 8, and on the peptide denatonium fragment using 870 ng/mL aminopeptidase n = 5. All data are presented as mean ± s.d. and each experiment was repeated at least once