Fig. 3
From: Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
Tissue-specific transcriptional responses induced by poliovirus infection. a Line plot showing the gene expression profiles for 341 genes in liver and kidney from Tg21 mice infected with WT poliovirus at 107 PFU by I.P. inoculation route. (n = 3, the number of mice is three for each time point and each group). Gene expression profiles across all experimental conditions were clustered to yield 5 clusters (Methods). Each gene’s trajectory is shaded by its cluster and the mean trajectory for each cluster is shown as a thick line. b Multidimensional scaling plot of the transcriptional response trajectories in liver and kidney. Each point represents the mean transcriptional response of three mice. Shaded ovals are drawn to emphasize the distinct trajectories of liver and kidney responses in infected mice. c Scatter plot showing the relative induction of genes in liver and kidney at 1 (left) and 3 (right) days postinfection. Genes are colored by cluster. d A multidimensional scaling plot of the coregulatory relationships between genes. Genes are arranged by the similarity of their expression response (determined by Euclidian distance) and colored by cluster. e Known innate immune and antiviral genes group together in clusters 1 and 5
