Fig. 8 | Nature Communications

Fig. 8

From: Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription

Fig. 8

Model proposed for TSHR signaling at the TGN based on the results of this study. Upon TSH stimulation, TSH/TSHR complexes internalize and traffic retrogradely to the TGN, leading to local Gs-protein activation in the retromer-coated compartment (RCC) and cAMP/PKA signaling at the Golgi/TGN, which is critically positioned near the nucleus. This appears required for efficient PKA-dependent CREB phosphorylation and the induction of early genes in response to TSH, which in thyroid cells is known to ultimately lead to increased thyroid hormone production and cell proliferation

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