Fig. 7
Knockdown of CDYL enhanced Nav1.6-mediated current. a Representitive sodium current traces obtained from normal control (NC), nonsilencing-shRNA-infected and CDYL-shRNA-infected rat DG neurons. Sodium currents were evoked by step depolarization from soma. b–d Graphs showing the density of peak sodium currents, activation curves and half-activation values of sodium currents, respectively. **p < 0.01, one-way ANOVA with Bonferroni’s multiple-comparison test. e Representitive sodium current traces in the presence of 75 nM of 4,9-TTX. f–h Graphs showing the density of peak sodium currents, activation curves and half-activation values of sodium currents, respectively, in the presence of 75 nM of 4,9-TTX. The above experiments were all performed with rat DG neurons. **p < 0.01, one-way ANOVA with Bonferroni’s multiple-comparison test. Data were represented as mean ± s.e.m.
