Table 1 Association results for the top three genotyped SNPs at 11q22.2

From: Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk

SNP

Study

A1/A2

Freq1

Freq2

OR

95% CI

P value

rs10895322

Discovery

G/A

0.164

0.064

2.858

1.991–4.101

2.62 × 10−9

 

Replication

G/A

0.131

0.057

2.478

1.296–4.740

4.58 × 10−3

 

Combined

   

2.763

2.015–3.789

2.89 × 10−10

rs3781788

Discovery

T/C

0.201

0.091

2.505

1.794–3.497

2.46 × 10−8

 

Replication

T/C

0.148

0.087

1.813

0.995–3.301

0.0486

 

Combined

   

2.321

1.733–3.106

1.58 × 10−8

rs2280211

Discovery

C/T

0.208

0.092

2.604

1.875–3.615

3.11 × 10−9

 

Replication

C/T

0.148

0.088

1.795

0.986–3.269

0.0525

 

Combined

   

2.390

1.792–3.187

3.16 × 10−9

  1. A1/A2: risk allele/protective allele
  2. Freq1: case frequency
  3. Freq2: control frequency
  4. P: P value calculated by logistic regression test
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