Fig. 1
From: Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ
Biosynthesis of nosiheptide by S. actuosus. a Organization of the nosiheptide biosynthetic gene cluster. Genes involved in the biosynthesis of the indolyl side ring (nosI, nosJ, nosK, nosL and nosN) are shown in red. b Nosiheptide contains an indolyl side ring that is not derived from the precursor peptide NosM. The NosL-derived indolic acid moiety (highlighted in blue) is a major component of the side ring, and the carbon atom introduced by the radical SAM methyltransferase NosN is highlighted with a red triangle. The nosN-knockout mutant of S. actuosus does not produce nosiheptide but an off-pathway product 2
