Fig. 2
From: Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
Downregulation of Sirt6 in renal biopsies from patients with different forms of podocytopathies. a Representative photomicrographs of Sirt6 immunohistochemical staining in human renal cortical tissue from normal subjects (n = 9), patients with focal segmental glomerulosclerosis (FSGS, n = 10), membranous glomerulonephritis (MGN, n = 8), IgA nephropathy (IgA, n = 9); diabetic nephropathy (DN) (n = 8), or diabetic patients without nephropathy (DM-NN). Scale bar: black 100 μm, red 25 μm. (n = 7). b Relative mRNA levels of Sirt6 in the renal biopsies from patients with different forms of podocytopathies. c Positive correlation (Spearman r = 0.5222, P < 0.01) between Sirt6 mRNA levels and estimated glomerular filtration rate (GFR) in all subjects. d Negative correlation (Spearman r = −0.6358, P < 0.01) between Sirt6 mRNA levels and proteinuria in all subjects. *P < 0.05 vs. normal subjects. Data are expressed as means ± SE. One-way ANOVA followed by Tukey’s post-test for multiple comparisons was used for groups of three or more
