Fig. 5
From: An allosteric ligand-binding site in the extracellular cap of K2P channels
Different conformations of TREK-1 obtained from MD simulations. a Conformation of TREK-1 in the apo system Sapo. b Conformation of TREK-1 in the complex system Scomplex with TKDC. The protein is shown as a cartoon. The extracellular E2 helix (cyan) and the selectivity filter below (green and yellow) are shown as surfaces. The filter in green and the E2 helix in cyan are in the same subunit. The yellow filter is in the other subunit. TKDC is shown as sticks. The red dashed arrow represents the conductive pathway. The red solid arrows indicate the movement of the E2 helix under the influence of TKDC. All illustrations are from the end of simulation runs
