Fig. 6
From: An allosteric ligand-binding site in the extracellular cap of K2P channels
Inhibitors of TREK-1 identified in structure-based virtual screening. a Cartoon showing superimposed binding models of 25 hits. b Chemical structures of the discovered inhibitors of TREK-1. c Dose-dependent inhibition of TREK-1 by TKN1 and TKN2. IC50 values were obtained via dose–response fitting
