Fig. 7
From: An allosteric ligand-binding site in the extracellular cap of K2P channels
Chronic administration of TKDC in mice. a Time spent immobile in the forced swimming test after administration of TKDC and fluoxetine (FLX) [one-way ANOVA with post hoc LSD test, F (4,55) = 4.20]. Veh indicates the vehicle-treatment group. TKDC was administered at doses of 0.5, 1 and 5 mg kg−1. Fluoxetine was administered at a dose of 10 mg kg−1. b Time spent immobile in the tail suspension test after administration of TKDC and fluoxetine [one-way ANOVA with post hoc LSD test, F (4,53) = 2.55]. c Percentage of distance traveled in the center of the field over the total distance traveled after administration of TKDC and fluoxetine in the open field test (one-way ANOVA with post hoc LSD test, F (4,51) = 3.81). d Total distance traveled after administration of TKDC and fluoxetine in the open field test (one-way ANOVA with post hoc LSD test, F (4,51) = 2.02). The numbers in the bars indicate the number of cells studied per condition. The results are shown as the mean ± s.e.m; * indicates P < 0.05, ** indicates P < 0.01
