Fig. 5
From: Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
Effects of Panobinostat on hepcidin in disease models of iron overload. a Effects of 3 days 20 mg/kg/d i.p. PB vs control on 15-week-old HFE−/− on liver Hamp1 mRNA, Id1 mRNA, and Bmp6 mRNA expression; liver non-heme iron content, and transferrin saturation. b Effects of Panobinostat 5 mg/kg/d for 7 days on 8–24-week-old HbbTh3/+ (Th3/+) mice on serum hepcidin levels, transferrin saturation, serum iron, and liver non-heme iron concentrations. Student’s t-test. Data are means ± s.e.m. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001; NS, P > 0.05
