Fig. 8 | Nature Communications

Fig. 8

From: Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Fig. 8

Schematic of FRC–B cell interactions resulting in mLN lymphangiogenesis following Hp infection. Lymphotoxin expression by IL-4- and antigen-activated B cells (1) signals to LTβR expressed by FRCs (2) to promote the expression of BAFF (3). BAFF then synergizes with IL-4 to further upregulate lymphotoxin expression on antigen-activated B cells in a feed-forward manner that acts to amplify total BAFF levels (4). BAFF and IL-4 then synergize to promote VEGF production by B cells (5) which drives helminth-induced lymphangiogenesis and continued DC accumulation within the mLN (6). FRC-derived BAFF also stimulates lymphotoxin expression by interacting B cells creating a feed-forward loop that furhter promotes FRC activation (7)

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