Fig. 7 | Nature Communications

Fig. 7

From: Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

Fig. 7

Schematic representation of hypoxia-induced MDSC accumulation. Hypoxia stabilizes HIF-1α in cancer cells. HIF-1α binds to the HRE in the promoter of ENTPD2 to initiate transcription in cancer cells. ENTPD2 facilitates the dephosphorylation of extracellular ATP into 5′-AMP. Increase in extracellular 5′-AMP prevents M-MDSCs from maturation at tumor sites, thereby promoting tumor-mediated immune escape. Inhibition of ENTPD2 reduces the number of tumor-infiltrating MDSCs and increase the efficacy of PD-1/CTLA-4 immune checkpoint inhibitors

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