Fig. 1
From: The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
RPKO strains exhibit changes at multiple levels of gene expression. a Heatmap depicts mean fold-changes of components of the indicated KEGG pathways at mRNA (measured by mRNA-seq), translation efficiency (calculated by dividing the normalized read count in Ribo-seq by the normalized read count in mRNA-seq), and protein (measured by proteomics) levels. The orange box highlights ribosome-related genes, whereas purple boxes highlight gene categories involved in amino acid biosynthesis and metabolism. b, c Specific examples of KEGG pathways whose components are regulated b translationally (2-oxocarboxylic acid metabolism) or c transcriptionally (tryptophan metabolism). Red dots represent genes from the indicated KEGG pathways and the contour plots refer to all genes
