Fig. 3

Regional association plot for the rearrangement near MC4R. The blue dots represent –log10 BMI-association P values, the red dots show the corresponding effect sizes. At the bottom the black and gray lines are the deletions and duplications frequencies. Finally, the dots at the bottom are the probes positions for the GIANT cohorts above and the UK BioBank below. Positions of the protein-coding genes are shown at the top of the plot along with the position of the BMI-associated GWAS SNP. The probes positions correspond to the human genome build 36