Fig. 5

Synthesis of moclobemide applying atmospheric CO₂. A three-chamber system was adapted including a chamber A containing a CO₂ binder 15 (5.0 mmol) in dimethyl sulfoxide, which was bubbled with dry air for 6 days. The second chamber B was set up as above for the production of 1.5 mmol CO employing an applied voltage of 3.6 V. In chamber C, a 0.5 mmol scale aminocarbonylation reaction was set-up including aryl iodide 2 (0.5 mmol) and amine 3 (1.0 mmol) with Xantphos Pd G4 (5 mol%) and DABCO (2 equiv.) in tetrahydrofuran