Fig. 3
From: Caloric restriction delays age-related methylation drift
Cross-species comparison of aging drift. a The association between age (x axis) and methylation percentage of 10 hypermethylated ARM genes (y axis) homologous in each species. Dots represent methylation values at 10 genes in each individual (mouse; young, n = 6, middle, n = 13, old, n = 12, monkey; infant, n = 12, middle, n = 15, old, n = 12, human; newborn, n = 13, young, n = 54, middle, n = 27, old, n = 45). p-values of the linear regression slope were calculated by t-test (two-tailed). b The association between methylation drift rate and lifespan. The x axis represents maximum longevity of each species (mouse; 4 years, monkey; 40 years, human; 122.5 years), and the y axis represents methylation changes per year. The scales are logarithmic. The maximum longevities of the three species were obtained from The Animal Ageing and Longevity Database (http://genomics.senescence.info/species/). The R-squared values and their p-values (F-test, two-tailed) were calculated
