Fig. 5
From: Caloric restriction delays age-related methylation drift
CR effects on aging drift detected by bisulfite pyrosequencing assays. a, b Unsupervised hierarchical clustering analysis of the loci assayed by bisulfite pyrosequencing showing aging methylation drift and the effect of CR in whole blood in mice and monkeys. The green to red color scale indicates the methylation percentage. The color codes of caloric status and age are shown on the bottom-right. c Differences between the age predicted based on methylation and the chronological age. Predicted age was calculated using the mixed linear model and data from bisulfite pyrosequencing assays. Each pair of dots connected by a line represents the difference between predicted age and chronological age in each individual. Paired t-test was used for p-value calculation
