Fig. 2

Global representation of the patterns of responses to individual or combined stimulations for 37 MMel. a, b Venn diagram representing each stimulating axis alone a or in combination b per circle, patients being identified by letters and numbers. c Frequencies of patient lesions that failed to respond to a given axis (first bar, in red) but could exhibit significant responses to alternative axis of stimulation. (second and third bar in green and blue). For instance (very left bars), in the non-responding lesions (NR) to anti-CTLA-4 Ab, we annotated the percentages that could respond (or not) to anti-CTLA-4 + anti-PD-1 Ab co-blockade (in green), among which some of them could respond (or not) to anti-PD-1 Ab alone (in blue). The detailed patterns of responses feature in Supplementary Table 1. In gray boxes: Not Done