Fig. 5

Predictive values of PD-L1⁺/CD8⁺ and CD95⁺/CD4⁺ for RR to ipilimumab. a, b Statistical analyses of the clinical relevance of CD95 expression on CD4⁺ T cells as well as PD-L1 on CD8⁺ T cells according to RR (separating PD from SD, PR, or CR) were performed in univariate and multivariate regression assays. Each dot represents one patient. The box plots indicating the mean and s.e.m. of values for the binary separation are depicted (cf Supplementary Table 4). The absolute numbers of patients are indicated in all groups in parentheses. Box and whiskers plots are represented from the corresponding distribution a, b