Fig. 1
From: The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
A-769662 activation of cellular AMPK signaling is dependent on β1-pSer108. a Reconstitution of basal AMPK signaling in AMPK β1/2 double knockout (β1/2-dKO) iMEFs by lentiviral transduction of AMPK β1 WT or S108A mutant. b Immunoblots for pACC from β1/2-dKO iMEFs-expressing β1 WT or S108A mutant, stimulated with 20 μM A-769662 for 90 min. n = 3. Error bars, mean pACC fold change relative to basal ± s.e.m. Statistical analysis was performed using unpaired two-tailed Student’s t-test. **P < 0.01 indicates significant increase in pACC compared to basal
