Fig. 5

RRM3 molecular dynamics simulation. Snapshots of the free RRM3 wild-type MD simulation showing the transition from UP to DOWN conformation. The C-terminus is colored in red, aromatic residues in the trans, gauche + and gauche − conformation are colored in green, orange and yellow, respectively. Glu418 and Lys499 are depicted in cyan. Time points and key events in the side-chain rearrangement are indicated. * All residues are in the UP state except of the mobile Phe466