Fig. 6
Schematic model of the interactions between CDA and Tau. a The simultaneous silencing of Tau and CDA increased genetic instability, as illustrated by the increases in γ-H2AX and 53BP1 focus events and UFB frequency. The accumulation of DNA damage and replication stress led to a decrease in clonal growth, and, thus, to cell death. b Tau downregulation affected rRNA synthesis by decreasing UBTF recruitment to rDNA promoters, thereby impairing the transcription of rDNA. By contrast, Tau overexpression in CDA-deficient cells led to an increase in rDNA transcription. Finally, Tau downregulation decreased the size of the intracellular ribonucleotide pools, consistent with previous reports linking decreases in rRNA production to imbalances in ribonucleotide pools
