Fig. 2

Mutational landscapes in the TD cohort and the NTD cohort. Somatic mutations in the TD and NTD cohort. Top, the number of silent and non-silent mutations of each sample. Middle, ESCC-associated genes in different pathways are ranked based on the mutation frequency. The heat map on the right indicates the frequency of each mutated gene in NTDs, dysplasia samples, and ESCCs over cases, respectively. Bottom, histopathological types of the samples in each case are indicated in different colors. Samples are displayed as columns